4-Methylmorpholine → N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamide

HRID 747658노트

반응식

HRID 747658 반응식
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)#[N:2].CN1CCOCC1.ClC(OCC)=O.[NH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=1)[C:32]#[N:33]>CN(C)C=O.C(OCC)(=O)C>[C:32]([C:31]1[CH:30]=[C:29]([CH:36]=[CH:35][CH:34]=1)[O:28][CH2:27][CH2:26][NH:25][C:7](=[O:9])[C:6]1[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=1)#[N:33]

참가 물질

7

반응물 4

HCID 79724-MethylmorpholineHCID 10928Ethyl chloroformateHCID 120874-Cyanobenzoic acidHCID 109098773-(2-Aminoethoxy)benzonitrile

생성물 1

HCID 11066232N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamide

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

1.13 g (7.68 mmol) of 4-cyanobenzoic acid and 1.6 ml (14.1 mmol) of N-methylmorpholine were dissolved in 30 ml of dimethylformamide. 0.67 ml (7.05 mmol) of ethyl chloroformate was added to the solution under cooling with ice/water. After stirring for 5 minutes, 1.27 g (6.41 mmol) of 3-(2-aminoethoxy)benzonitrile was added to the reaction mixture, and the obtained mixture was stirred at room temperature for one hour. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained.

후처리

  1. stirringthe obtained mixture was stirred at room temperature for one hour

출처 및 근거

ORD 기록
ord-437a3928bfc14457a81bb047c2de8364
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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