Ethylenediamine → ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

HRID 747667

반응식

HRID 747667 반응식
Cl.C(O[C:5]([C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:8]=1)=[NH:6])C.[CH2:18](N)[CH2:19][NH2:20]>C(O)C>[NH:20]1[CH2:19][CH2:18][N:6]=[C:5]1[C:7]1[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 3301EthylenediamineHCID 68830640Ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride

생성물 1

HCID 22709787ethyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.96 g (11.5 mmol) of ethyl 4-ethoxycarbonimidoylbenzoate hydrochloride and 690 mg (11.5 mmol) of ethylenediamine were stirred in 100 ml of ethanol at 60° C. for 4 hours. The solvent was evaporated. 1 N aqueous sodium hydroxide solution was added to the residue. After the extraction with dichloromethane followed by the washing with saturated Aqueous NaCl solution and drying over anhydrous magnesium sulfate, the solvent was evaporated to obtain the title compound.

후처리

  1. customThe solvent was evaporated
  2. addition1 N aqueous sodium hydroxide solution was added to the residue
  3. extractionAfter the extraction with dichloromethane
  4. dry with materialdrying over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-cb7ec3e54e204604bbb02da5465f2b1c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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