Triethylamine → t-Butyl 4-(4-methoxycarbonylbenzoyl)piperazine-1-carboxylate

HRID 747682노트

반응식

HRID 747682 반응식
[N:1]1([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Cl-].[C:22]([O:33][CH3:34])(=[O:32])[C:23]1[CH:31]=[CH:30][C:26]([C:27]([O-])=[O:28])=[CH:25][CH:24]=1>CN(C)C=O.Cl>[CH3:34][O:33][C:22]([C:23]1[CH:31]=[CH:30][C:26]([C:27]([N:4]2[CH2:5][CH2:6][N:1]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:2][CH2:3]2)=[O:28])=[CH:25][CH:24]=1)=[O:32]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 22493623Monomethyl terephthalate chloride

생성물 1

HCID 17789205t-Butyl 4-(4-methoxycarbonylbenzoyl)piperazine-1-carboxylate

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6228Dimethylformamide용매

실험 절차

4.93 g (26.5 mmol) of t-butyl piperazine-1-carboxylate and 4.8 ml (34.5 mmol) of triethylamine were stirred in 50 ml of dimethylformamide under cooling with ice. 5.25 g (26.5 mmol) of monomethyl terephthalate chloride was slowly added to the resultant mixture, and they were stirred for 16 hours. The temperature was elevated to room temperature, and the reaction liquid was diluted with 1 N hydrochloric acid. After the extraction with ethyl acetate followed by the treatment in an ordinary manner, the title compound was obtained.

후처리

  1. temperatureunder cooling with ice
  2. customwas elevated to room temperature
  3. customthe reaction liquid
  4. extractionAfter the extraction with ethyl acetate

출처 및 근거

ORD 기록
ord-f920af3f16aa4415b543e2effaf1a3a1
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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