Hydrochloric Acid → Ethyl 4-(3-cyanophenoxy)-2-butenoate

HRID 747715노트

반응식

HRID 747715 반응식
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].[OH:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Cl>CN(C)C=O>[C:14]([C:13]1[CH:12]=[C:11]([CH:18]=[CH:17][CH:16]=1)[O:10][CH2:2][CH:3]=[CH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:15]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 5373944Ethyl (E)-4-bromobut-2-enoate

생성물 1

HCID 54098496Ethyl 4-(3-cyanophenoxy)-2-butenoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1 g (3.9 mmol) of ethyl 4-bromocrotonate, 465 mg (3.9 mmol) of 3-hydroxybenzonitrile, 539 mg (3.9 mmol) of potassium carbonate and 647 mg (3.9 mmol)) of potassium iodide were stirred in N,N-dimethylformamide at room temperature for 3 days. 1 N hydrochloric acid was added to the reaction liquid. After the extraction with ethyl acetate, the extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

후처리

  1. extractionAfter the extraction with ethyl acetate
  2. washthe extract was washed with 1 N aqueous sodium hydroxide solution and saturated aqueous common salt solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-1e09a9720de24a10a2518ff677d1b241
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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