Benzyl Bromide → HCID 68836020, 화합물

HRID 747747노트

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HRID 747747 반응식
[H-].[Na+].[C:3]([C:5]1[CH:6]=[C:7]([CH:22]=[CH:23][CH:24]=1)[O:8][CH2:9][CH2:10][NH:11][C:12](=[O:21])[C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=1)#[N:4].[H][H].[CH2:27](Br)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C)C=O>[C:3]([C:5]1[CH:6]=[C:7]([CH:22]=[CH:23][CH:24]=1)[O:8][CH2:9][CH2:10][N:11]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:12](=[O:21])[C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=1)#[N:4]

참가 물질

6

반응물 4

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 11066232N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 68836020HCID 68836020, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

28 mg (0.7 mmol) of sodium hydride (oily, 60%) was stirred in dimethylformamide under cooling with ice. A solution of 200 mg (0.69 mmol) of N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamide in a small amount of dimethylformamide was added thereto. After the completion of the generation of hydrogen, 257 mg (1.5 mmol) of benzyl bromide was added to the mixture, and they were stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure. 1N aqueous hydrogen chloride solution was added to the residue. The same procedure for the isolation as that of step 1 in Example 1 was repeated with ethyl acetate as the extractant to obtain the title compound.

후처리

  1. temperatureunder cooling with ice
  2. customThe solvent was evaporated under reduced pressure
  3. addition1N aqueous hydrogen chloride solution was added to the residue

출처 및 근거

ORD 기록
ord-68a4618e5a1a4f04bfb74452ca7ecf19
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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