Methyl 6-pyrrolidinonicotinate → 6-(Pyrrolidin-1-yl)nicotinic acid

HRID 747793노트

반응식

HRID 747793 반응식
[N:1]1([C:6]2[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([C:6]2[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

3

반응물 1

HCID 2794748Methyl 6-pyrrolidinonicotinate

생성물 1

HCID 7380556-(Pyrrolidin-1-yl)nicotinic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
40 °C

실험 절차

1.0 g (4.85 mol) of methyl 6-(pyrrolidine-1-yl)nicotinoate was dissolved in 10 ml of conc. hydrochloric acid and stirred at 40° C. overnight. The solvent was distilled off whereby the hydrochloride of the title compound was obtained.

후처리

  1. distillationThe solvent was distilled off whereby the hydrochloride of the title compound
  2. customwas obtained

출처 및 근거

ORD 기록
ord-55c46c1b6dc24d8aa997a33dcc511499
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396844B1

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