Methyl chloroformate → 4-Fluoro-2-methylphenyl Methoxyformate

HRID 7479

반응식

HRID 7479 반응식
Cl[C:2]([O:4][CH3:5])=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:14])[CH:8]=1>[OH-].[Na+]>[C:2](=[O:3])([O:4][CH3:5])[O:13][C:10]1[CH:11]=[CH:12][C:7]([F:6])=[CH:8][C:9]=1[CH3:14]

참가 물질

4

반응물 2

HCID 6586Methyl chloroformateHCID 1362954-Fluoro-2-methylphenol

생성물 1

HCID 106790444-Fluoro-2-methylphenyl Methoxyformate수율 78.4%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Methyl chloroformate (6.8 ml, 88 mmol) was added over 30 minutes to a solution of 4-fluoro-2-methylphenol (10 g, 79 mmol) in 6% aqueous sodium hydroxide solution at 0° C. The mixture was stirred for 2 hours, then extracted with ethyl acetate (100 ml). The ethyl acetate extract was washed with water (100 ml) and dried (MgSO4) and the solvent removed by evaporation to give 4-fluoro-2-methylphenyl methyl carbonate (11.4 g, 78%) as an oil.

후처리

  1. extractionextracted with ethyl acetate (100 ml)
  2. extractionThe ethyl acetate extract
  3. washwas washed with water (100 ml)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-3fadd27d35ed4579aa61b756ed318a83
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087602B2

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