Hydrogen Bromide → HCID 59750636, 화합물

반응식

C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][OH:13])[CH2:6]2.Br>>[OH:13][CH2:12][CH:7]1[CH2:6][C:5]2[C:9](=[CH:10][CH:11]=[C:3]([OH:2])[CH:4]=2)[CH2:8]1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 23044254(5-Methoxy-indan-2-yl)-methanol

생성물 1

HCID 59750636HCID 59750636, 화합물수율 63.1%

실험 절차

Combine (5-Methoxy-indan-2-yl)-methanol (117.0 mg, 0.65 mmol), and 48% HBr(aq). After the reaction refluxes for 30 minutes, cool to room temperature and extract the product with ethyl acetate. Wash with brine and dry over Na2SO4. After concentrating the organic layer under reduced pressure, flash chromatograph using 2/1 Hexanes/Ethyl acetate eluent to afford 67.3 mg, 0.41 mmol (63% yield) of the title compound: 1H NMR (500 MHz, CDCl3); 2.6-2.8 (3H, m), 2.9-3.1 (2H, m), 3.6-3.8 (2H, m), 6.6-6.8 (2H, m), 7.0-7.1 (1H, m); TLC 1:1 Hexanes:Ethyl acetate Rf:=0.3.

후처리

extractionextract the product with ethyl acetate
washWash with brine
dry with materialdry over Na2SO4
concentrationAfter concentrating the organic layer under reduced pressure, flash chromatograph

출처 및 근거

ORD 기록: ord-60dd52c903864ea88489eb5fd1188c90
출처 데이터셋: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07399774B2

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