Sodium Hydroxide → 5-Amino-4-fluoro-2-methylphenol
반응식
[F:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[OH-].[Na+]>O.[Fe].S([O-])([O-])(=O)=O.[Fe+2]>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([OH:11])=[CH:6][C:7]=1[NH2:8]참가 물질
6
실험 절차
A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.
후처리
- temperaturewas heated
- temperatureat reflux for 4 hours
- temperatureto cool
- extractionextracted with ethyl acetate (100 ml)
- extractionThe ethyl acetate extract
- dry with materialwas dried (MgSO4)
- customthe solvent removed by evaporation
출처 및 근거
- ORD 기록
- ord-994883380a214f47b45d3a084572d5ee
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087602B2
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