Sodium Hydroxide → 5-Amino-4-fluoro-2-methylphenol

HRID 7481

반응식

HRID 7481 반응식
[F:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[OH-].[Na+]>O.[Fe].S([O-])([O-])(=O)=O.[Fe+2]>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([OH:11])=[CH:6][C:7]=1[NH2:8]

참가 물질

6

반응물 2

HCID 14798Sodium HydroxideHCID 108210594-Fluoro-2-methyl-5-nitrophenol

생성물 1

HCID 101540985-Amino-4-fluoro-2-methylphenol수율 47%

시약·촉매·용매 3

HCID 23925Iron촉매HCID 24393Ferrous Sulfate촉매HCID 962Water용매

실험 절차

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. temperatureto cool
  4. extractionextracted with ethyl acetate (100 ml)
  5. extractionThe ethyl acetate extract
  6. dry with materialwas dried (MgSO4)
  7. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-994883380a214f47b45d3a084572d5ee
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087602B2

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