[CH2:1]([SH:3])[CH3:2].[H-].[Na+].[O:6]=[C:7]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[S:10][C:9]([C:17]2[N:22]=[C:21]([CH2:23]S([O-])(=O)=O)[CH:20]=[CH:19][CH:18]=2)=[N:8]1.C(OCC)(=O)C>CN(C=O)C.O>[CH2:1]([S:3][CH2:23][C:21]1[N:22]=[C:17]([C:9]2[S:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:7](=[O:6])[N:8]=2)[CH:18]=[CH:19][CH:20]=1)[CH3:2]
Ethyl mercaptan (0.25 g, 3.30 mmol) and sodium hydride (60% in oil, 0.15 g, 3.60 mmol) were dissolved in DMF (30 ml), and 6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridylmethanesulfonate (1.05 g, 3.00 mmol) was added thereto. The reaction mixture was stirred at room temperature for 18 hrs and combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated, and the residue was recrystallized from n-hexane-ethyl acetate to give the titled compound (0.23 g, 24%) as pale yellow crystals.
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