Ethyl Acetate → 6-Chloro-1H-pyrrolo[2,3-b]pyridine
반응식
[Cl:1][C:2]1[N:7]=[C:6]2[N:8](C(C3C=CC=CC=3)=O)[CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[OH-].[Na+].C(OCC)(=O)C>CO>[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1참가 물질
5
실험 절차
A solution of (Intermediate C3) (3.12 mmol) in MeOH (90 mL) was treated with 1 M NaOH (30 mL) at rt for 18 h. The solution was freed of MeOH under reduced pressure and ethyl acetate was added to the aqueous layer. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with sat. NaHCO3, and dried over Na2SO4. The mixture was filtered and the solvent was evaporated to give a solid 6-chloro-1H-pyrrolo[2,3-b]pyridine (Intermediate C4).
후처리
- additionwas added to the aqueous layer
- extractionThe aqueous layer was extracted with ethyl acetate
- washthe combined organic layers were washed with sat. NaHCO3
- dry with materialdried over Na2SO4
- filtrationThe mixture was filtered
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-12104a8f793c40f4a9680a0d47d24369
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07399868B2
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