Dimethyl Sulfoxide → 5-((tert-Butyldimethylsilyl)oxy)pentanal

HRID 748780노트

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HRID 748780 반응식
CS(C)=O.C(N(CC)CC)C.[Si:12]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][OH:25])([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13].[Cl-].[NH4+]>CCCCCC.ClCCl>[Si:12]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=[O:25])([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]

참가 물질

7

반응물 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 36143185-((Tert-butyldimethylsilyl)oxy)pentan-1-ol

생성물 1

HCID 109877035-((tert-Butyldimethylsilyl)oxy)pentanal수율 81.2%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8058Hexane용매

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온도
0 °C

실험 절차

Under a nitrogen atmosphere and at 0° C., dimethylsulfoxide (7.81 ml, 110 mmol), triethylamine (9.60 ml, 69.0 mmol), and a sulfur trioxide-pyridine complex (4.39 g, 27.6 mmol) were added to a dichloromethane solution (80 ml) of 5-(t-butyldimethylsilyloxy)pentanol (3.00 g, 13.8 mmol). The resulting mixture was stirred at 0° C. for 30 minutes and then, at room temperature for further 3 hours. After cooling to 0° C., a saturated aquoeus ammonium chloride solution was added. Dichloromethane was distilled off under reduced pressure. To the residue was added ethyl acetate. After the water layer was separated, the organic layer was washed with water and brine, dried over magnesium sulfate and then, concentrated. The residue thus obtained was subjected to chromatography on a silica gel column, and the fraction obtained from the hexane:ethyl acetate=20:1 eluate was concentrated, whereby the title compound (2.42 g, 11.2 mmol, 81%) was obtained as a colorless oil.

후처리

  1. waitat room temperature for further 3 hours
  2. temperatureAfter cooling to 0° C.
  3. distillationDichloromethane was distilled off under reduced pressure
  4. additionTo the residue was added ethyl acetate
  5. customAfter the water layer was separated
  6. washthe organic layer was washed with water and brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated
  9. customThe residue thus obtained
  10. concentrationethyl acetate=20:1 eluate was concentrated

출처 및 근거

ORD 기록
ord-c59df5db453846e3b9ec2d2902daf54c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07399775B2

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