참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 반응물 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 반응물 | 5-Bromo-1,3-dihydro-2-benzothiophene | HCID 59801489 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-Bromo-1,3-dihydro-benzo(c)thiophene 2,2-dioxide | HCID 288396 | 65% |
반응 단계
Dissolve 5-bromo-1,3-dihydro-benzo[c]thiophene (1.25 g, 5.79 mmol) in methanol (25 mL) and add oxone (10.7 g, 17.4 mmol). Stir the reaction mixture for 2 hours at 0° C. and then add a 1M aqueous sodium bisulfite solution (100 mL). Stir the reaction mixture for 10 minutes and add saturated NaHCO3 solution (200 mL). Extract the aqueous layer with CH2Cl2 (3×1 00 mL). Combine the organic layers and dry with Na2SO4, filter, concentrate and purify by flash column chromatography (silica gel, 0-5% MeOH/CH2Cl2) to give 930 mg of 5-bromo-1,3-dihydro-benzo[c]thiophene 2,2-dioxide (65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07399867B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_07 |
|---|
| ORD ID | ord-e2639faad0e841648df3139585c9550b |
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| 출처 메모 | uspto-grants-2008_07 |
|---|
