2-(Trifluoromethyl)aniline → HCID 68973195, 화합물

HRID 749049노트

반응식

HRID 749049 반응식
CN1CCOCC1.[F:8][C:9]([F:18])([F:17])[C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12].[O:19]=[C:20]1[CH2:37][CH2:36][C@@:35]2([CH3:38])[C:22]([CH2:23][CH2:24][C@@H:25]3[C@@H:34]2[CH2:33][CH2:32][C@@:30]2([CH3:31])[C@H:26]3[CH2:27][CH2:28][C@@H:29]2[C:39](Cl)=[O:40])=[CH:21]1>C(Cl)Cl>[O:19]=[C:20]1[CH2:37][CH2:36][C@@:35]2([CH3:38])[C:22]([CH2:23][CH2:24][C@@H:25]3[C@@H:34]2[CH2:33][CH2:32][C@@:30]2([CH3:31])[C@H:26]3[CH2:27][CH2:28][C@@H:29]2[C:39]([NH:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[C:9]([F:17])([F:18])[F:8])=[O:40])=[CH:21]1

참가 물질

5

반응물 3

HCID 69222-(Trifluoromethyl)anilineHCID 79724-MethylmorpholineHCID 117273863-Oxoandrost-4-ene-17beta-carbonyl chloride

생성물 1

HCID 68973195HCID 68973195, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of N-methylmorpholine (0.28 g, 2.8 mmol) and 2-(trifluoromethyl)aniline (0.5 g, 3.1 mmol) in anhydrous CH2Cl2 (3.0 mL) at 0° C. under a nitrogen atmosphere was added a solution of 3-oxoandrost-4-ene-17β-carbonyl chloride from Step A (2.56 mmol) in anhydrous CH2Cl2 (8.1 mL) dropwise. The ice bath was removed and the mixture stirred at room temperature overnight. The reaction was then concentrated and the residue was purified by flash chromatography on silica gel eluting with 0 to 50% EtOAc-hexanes to afford the desired product as a white solid.

후처리

  1. customThe ice bath was removed
  2. concentrationThe reaction was then concentrated
  3. customthe residue was purified by flash chromatography on silica gel eluting with 0 to 50% EtOAc-hexanes

출처 및 근거

ORD 기록
ord-ac4f7277ab204c88874899af40acec3c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402577B2

반응 노트

불러오는 중…