참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzenesulfonamide, 3-[4-[(6-bromohexyl)oxy]butyl]- | HCID 21895438 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-(4-{[6-(Benzylamino)hexyl]oxy}butyl)benzenesulfonamide | HCID 69315689 | 50.6% |
반응 단계
3-[4-(6-Bromo-hexyloxy)-butyl]benzenesulfonamide (1.0 g) in toluene (4 ml) was added dropwise to benzylamine (0.65 g) and the resulting mixture heated at 80° C. for 6 h. The mixture was then cooled and 20% aqueous sodium hydroxide solution (50 ml) was added. The resulting mixture was extracted with ethyl acetate and the combined organic layers evaporated to dryness in vacuo. The residual oil was then purified by chromatography (DCM-IMS-NH3(aq) 100:10:1) to give the title compound (0.54 g) LC RT=3.89 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07402598B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_07 |
|---|
| ORD ID | ord-bd3f499aa4be4adf9a9b12a82dd0a673 |
|---|
| 출처 메모 | uspto-grants-2008_07 |
|---|
