Sodium hydride → 2-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile

HRID 749520

반응식

HRID 749520 반응식
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].[H-].[Na+].[C:14]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21]Br)=[CH:19][CH:18]=1)(=[O:16])[CH3:15]>CN(C)C=O>[C:14]([C:17]1[CH:24]=[CH:23][C:20]([CH2:21][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])=[CH:19][CH:18]=1)(=[O:16])[CH3:15]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 5837851-[4-(Bromomethyl)phenyl]ethan-1-oneHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

생성물 1

HCID 222350392-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile수율 79%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.3 g of (3,3,3-trifluoropropyl)malononitrile, 3 ml of N,N-dimethylformamide, 0.08 g of sodium hydride (60% in oil), and 0.4 g of 4-acetylbenzyl bromide, and according to the process described in the Production Example 1, there was obtained 0.43 g of 2-(4-acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (6)).

출처 및 근거

ORD 기록
ord-b959e0b912e0481d9446d9479abfd2e8
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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