2-(Phenylmethyl)propanedinitrile → 2-Benzyl-2-(3,3,3-trifluoropropyl)malononitrile

HRID 749525

반응식

HRID 749525 반응식
[CH2:1]([CH:8]([C:11]#[N:12])[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19]>CN(C)C=O>[CH2:1]([C:8]([CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])([C:9]#[N:10])[C:11]#[N:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 158462-(Phenylmethyl)propanedinitrileHCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropane

생성물 1

HCID 222349692-Benzyl-2-(3,3,3-trifluoropropyl)malononitrile수율 17.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.50 g of benzylmalononitrile, 10 ml of N,N-dimethylformamide, 0.14 g of sodium hydride (60% in oil), and 0.63 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.14 g of 2-benzyl-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (12)).

출처 및 근거

ORD 기록
ord-1217c89f9dd54bf98a3dc841439837e0
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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