2-((4-Chlorophenyl)methyl)propanedinitrile → 2-(4-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile

HRID 749528

반응식

HRID 749528 반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]([C:10]#[N:11])[C:8]#[N:9])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:17][CH2:18][C:19]([F:22])([F:21])[F:20]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([CH2:17][CH2:18][C:19]([F:22])([F:21])[F:20])([C:8]#[N:9])[C:10]#[N:11])=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 180822-((4-Chlorophenyl)methyl)propanedinitrileHCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropane

생성물 1

HCID 222349702-(4-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile수율 22%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-dimethylformamide, 1.0 g of sodium hydride (60% in oil), and :0.93 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.21 g of 2-(4-chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (15)).

출처 및 근거

ORD 기록
ord-3275d3997d7d4f44a7061f72f4aaba53
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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