2-((4-Chlorophenyl)methyl)propanedinitrile → 2-(4-Chlorobenzyl)-2-(3,3,4,4,4-pentafluorobutyl)malononitrile

HRID 749536

반응식

HRID 749536 반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][CH:7]([C:10]#[N:11])[C:8]#[N:9])=[CH:4][CH:3]=1.[H-].[Na+].I[CH2:17][CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([CH2:17][CH2:18][C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])([C:8]#[N:9])[C:10]#[N:11])=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 180822-((4-Chlorophenyl)methyl)propanedinitrileHCID 24758Sodium hydrideHCID 1100921,1,1,2,2-Pentafluoro-4-iodobutane

생성물 1

HCID 222349762-(4-Chlorobenzyl)-2-(3,3,4,4,4-pentafluorobutyl)malononitrile수율 28%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-dimethylformamide, 0.21 g of sodium hydride (60% in oil), and 1.44 g of 4-iodo-1,1,1,2,2-pentafluorobutane, and according to the process described in the Production Example 1, there was obtained 0.47 g of 2-(4-chlorobenzyl)-2-(3,3,4,4,4-pentafluorobutyl)malononitrile (the present compound (23)).

출처 및 근거

ORD 기록
ord-516dd3315ab841968b97b25fa71d36dc
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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