Sodium hydride → HCID 22234990, 화합물

HRID 749551노트

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HRID 749551 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5]Cl.[H-].[Na+].[F:16][C:17]([F:26])([F:25])[CH2:18][CH2:19][CH:20]([C:23]#[N:24])[C:21]#[N:22]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5][C:20]([CH2:19][CH2:18][C:17]([F:16])([F:25])[F:26])([C:21]#[N:22])[C:23]#[N:24]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 221857612-(3,3,3-Trifluoropropyl)malononitrileHCID 22234987Benzene, 2-chloro-4-(chloromethyl)-1-(trifluoromethyl)-

생성물 1

HCID 22234990HCID 22234990, 화합물수율 70%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.28 g of 3-chloro-4-(trifluoromethyl)benzyl chloride, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.25 g of 2-(3-chloro-4-(trifluoromethyl)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (39)).

출처 및 근거

ORD 기록
ord-7f63bbf1747645469a133505836f837f
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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