2-Fluoroethyl bromide → 2-(2-Fluoroethyl)-2-(4-methoxybenzyl)malononitrile

HRID 749561

반응식

HRID 749561 반응식
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:18][CH2:19][F:20]>CN(C)C=O>[F:20][CH2:19][CH2:18][C:8]([CH2:7][C:6]1[CH:13]=[CH:14][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)([C:11]#[N:12])[C:9]#[N:10]

참가 물질

5

반응물 3

HCID 129822-Fluoroethyl bromideHCID 24758Sodium hydrideHCID 27641412-(4-Methoxybenzyl)malononitrile

생성물 1

HCID 222349672-(2-Fluoroethyl)-2-(4-methoxybenzyl)malononitrile수율 50.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.37 g of (4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.25 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.23 g of 2-(2-fluoroethyl)-2-(4-methoxybenzyl)malononitrile (the present compound (52)).

출처 및 근거

ORD 기록
ord-7ffa2c9d066242a68b8b4864d8a6a3eb
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

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