Sodium hydride → 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile

HRID 749596

반응식

HRID 749596 반응식
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH:8]([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][C:8]([CH2:18][CH2:19][C:20]([F:23])([F:22])[F:21])([C:11]#[N:12])[C:9]#[N:10])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 27251143-Bromo-1,1,1-trifluoropropaneHCID 27641412-(4-Methoxybenzyl)malononitrile

생성물 1

HCID 222350142-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile수율 27.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Using 0.39 g of 2-(4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(4-methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (89)).

출처 및 근거

ORD 기록
ord-7bc74f264c974fa9b95d4105bebdbf2c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402691B2

연결된 노트

불러오는 중…