Benzoyl chloride → Benzanilide

HRID 749630

반응식

HRID 749630 반응식
[C:1]1([NH:7]C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:14]([NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 7412Benzoyl chlorideHCID 11487Diphenylamine

생성물 1

HCID 7168Benzanilide수율 230.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

830 mg (2.44 mmole) of the aniline compound obtained in step 1 was dissolved in 10 mL of pyridine, 0.340 mL (2.93 mmoles) of benzoylchloride was added, and the mixture was stirred overnight at room temperature. When the reaction had ended, the solvent was removed under reduced pressure. Ethyl acetate and 1N HCl aqueous solution were added to the residue. The mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine and dried with anhydrous sodium sulfate. The solvent was removed under reduced pressure, yielding 1.11 g of N-benzoylaniline compound.

후처리

  1. customthe solvent was removed under reduced pressure
  2. additionEthyl acetate and 1N HCl aqueous solution were added to the residue
  3. extractionThe mixture was extracted with ethyl acetate
  4. washThe obtained organic layer was washed with saturated brine
  5. dry with materialdried with anhydrous sodium sulfate
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-bd63148fe211469f996a363c66a2399c
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402696B2

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