Calcium Acetate → Acrylamide

HRID 750430

반응식

HRID 750430 반응식
C([O-])(=[O:3])C.[Ca+2].C([O-])(=[O:8])C.[C:10](#[N:13])[CH:11]=[CH2:12].[C:14](#[N:18])[C:15]([CH3:17])=[CH2:16].[OH:19][CH:20]([CH2:24][CH3:25])[CH2:21][C:22]#[N:23]>O>[C:10]([NH2:13])(=[O:3])[CH:11]=[CH2:12].[C:14]([NH2:18])(=[O:8])[C:15]([CH3:17])=[CH2:16].[OH:19][CH:20]([CH2:24][CH3:25])[CH2:21][C:22]([NH2:23])=[O:3]

참가 물질

8

반응물 4

HCID 6116Calcium AcetateHCID 7855AcrylonitrileHCID 31368MethacrylonitrileHCID 98554543-hydroxypentanenitrile

생성물 3

HCID 6579AcrylamideHCID 6595MethacrylamideHCID 149797283-Hydroxypentanamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

At the completion of the reaction (100% conversion of nitrile), the product mixture was decanted from the biocatalyst beads, and additional distilled, deionized water, 0.2 mL of 0.20 M calcium acetate buffer (pH 7.0, 2.0 mM final calcium ion concentration in reaction mixture) and 10, 20, 40 or 60 mmol of acrylonitrile, methacrylonitrile, or 3-hydroxy-valeronitrile mixed with the reaction heel (immobilized-cell catalyst and remaining product mixture from the first reaction) at 25° C. or 35° C. At the completion of the second reaction, the product mixture was decanted and a third reaction performed as before. The reaction time, product yield for acrylamide, methacrylamide, or 3-hydroxyvaleramide, and the percent recovered biocatalyst activity for each recycle reaction is listed in Table 11 below.

후처리

  1. customthe product mixture was decanted from the biocatalyst beads, and additional distilled
  2. additionmixed with the reaction heel (immobilized-cell catalyst
  3. customfrom the first reaction) at 25° C.
  4. custom35° C
  5. customAt the completion of the second reaction
  6. customthe product mixture was decanted
  7. customa third reaction

출처 및 근거

ORD 기록
ord-4d1d394c094b4ffdabf4d26c1dfe7bf0
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405064B2

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