Benzaldehyde → 1-Acetyl-3-tert-butylamino-2-phenyl-imidazo[1,2-a]-pyrimidin-1-ium chloride

HRID 7509

반응식

HRID 7509 반응식
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].[CH:14](=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:22]([Cl:25])(=[O:24])[CH3:23]>Cl(O)(=O)(=O)=O>[Cl-:25].[C:22]([N+:1]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:13]([NH:12][C:8]([CH3:11])([CH3:10])[CH3:9])[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]=12)(=[O:24])[CH3:23]

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 6367Acetyl chlorideHCID 79782-AminopyrimidineHCID 23577Tert-Butyl isocyanide

생성물 1

HCID 1784189151-Acetyl-3-tert-butylamino-2-phenyl-imidazo[1,2-a]-pyrimidin-1-ium chloride

시약·촉매·용매 1

HCID 24247Perchloric Acid용매

실험 절차

Example 3 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

출처 및 근거

ORD 기록
ord-5ebe5abfa2ca49b9841445d97976bc23
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087607B2

연결된 노트

불러오는 중…