Hydrochloric Acid → (2R,3S)-Methyl 3-hydroxypiperidine-2-carboxylate

HRID 751110노트

반응식

HRID 751110 반응식
Cl.[OH:2][CH:3]1[CH2:8][CH2:7][CH2:6][NH:5][CH:4]1[C:9]([OH:11])=[O:10].[CH3:12]O>>[CH3:12][O:10][C:9]([C@H:4]1[C@@H:3]([OH:2])[CH2:8][CH2:7][CH2:6][NH:5]1)=[O:11]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 138742223-Hydroxypipecolic acid

생성물 1

HCID 15337757(2R,3S)-Methyl 3-hydroxypiperidine-2-carboxylate

반응 조건

온도
0 °C

실험 절차

Hydrogen chloride gas was bubbled through a suspension of 3-hydroxy-piperidine-2-carboxylic acid (0.54 g, 0.370 mol) in MeOH (100 mL) cooled to 0° C. for 10 min. The resulting clear solution was stirred at rt for 4 h, then evaporated carefully under reduced pressure (white precipitates formed during the concentration). The resulting white solid was dried overnight under vacuum to afford 0.86 g of the title compound as an off-white powder.

후처리

  1. customevaporated carefully under reduced pressure (
  2. customwhite precipitates
  3. customformed during the concentration)
  4. customThe resulting white solid was dried overnight under vacuum

출처 및 근거

ORD 기록
ord-061909cafad247828ed1c4c398d15583
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405234B2

반응 노트

불러오는 중…