N,N,N',N'-Tetramethylazodicarboxamide → HCID 68821972, 화합물

HRID 751193

반응식

HRID 751193 반응식
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([OH:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].[F:17][C:18]([F:33])([F:32])[O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]#[C:27][CH2:28][CH2:29][CH2:30]O)=[CH:22][CH:21]=1.CN(C)C(N=NC(N(C)C)=O)=O.C(P(CCCC)CCCC)CCC>>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[C:10]([O:15][CH2:30][CH2:29][CH2:28][C:27]#[C:26][C:23]3[CH:24]=[CH:25][C:20]([O:19][C:18]([F:17])([F:32])[F:33])=[CH:21][CH:22]=3)[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

참가 물질

5

반응물 4

HCID 4278N,N,N',N'-TetramethylazodicarboxamideHCID 13831TributylphosphineHCID 68822476ethyl (4-hydroxy-1H-indol-1-yl)acetateHCID 688226904-Pentyn-1-ol, 5-[4-(trifluoromethoxy)phenyl]-

생성물 1

HCID 68821972HCID 68821972, 화합물

실험 절차

In analogy to the procedure described for example 1 d], (4-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with 5-(4-trifluoromethoxy-phenyl)-pent-4-yn-1-ol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give the title compound as colorless crystals.

후처리

  1. customdescribed for example 1 d

출처 및 근거

ORD 기록
ord-8ce05be325b04819ac74769e7fc0d2aa
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405236B2

연결된 노트

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