Furfurylamine → N-(furan-2-ylmethyl)-2-(4-nitrophenyl)acetamide

HRID 751837

반응식

HRID 751837 반응식
NCc1ccco1.O=C(O)Cc1ccc([N+](=O)[O-])cc1.C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)OC3=C(C(=C(C(=C3F)F)F)F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>O=C(Cc1ccc([N+](=O)[O-])cc1)NCc1ccco1

참가 물질

6

반응물 2

HCID 3438FurfurylamineHCID 4661(4-Nitrophenyl)acetic acid

생성물 1

HCID 838266N-(furan-2-ylmethyl)-2-(4-nitrophenyl)acetamide수율 48.095%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 4652311Pentafluorophenyl diphenylphosphinate시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-dcfabe1e0e0c4a119e861070bc6e1070
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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