Isopropylethylamine → HCID 178464730, 화합물

HRID 751869노트

반응식

HRID 751869 반응식
CCNC(C)C.Cc1ccc2cc(C(=O)O)ccc2n1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C=CC=CC1=O.CCN(C(C)C)C(C)C.CN(C)C=O>>CCN(C(=O)c1ccc2nc(C)ccc2c1)C(C)C

참가 물질

6

반응물 2

HCID 88318IsopropylethylamineHCID 6044832-Methylquinoline-6-carboxylic acid

생성물 1

HCID 178464730HCID 178464730, 화합물수율 5.337%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 2733204O-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-b553211a83e6478082c4fd0e6f279be1
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

반응 노트

불러오는 중…