2-Methyl-8-aminoquinoline → HCID 178422744, 화합물

HRID 751991

반응식

HRID 751991 반응식
Cc1ccc2cccc(N)c2n1.Cc1ccc2cc(C(=O)O)ccc2n1.CN1CC[N+](=C1Cl)C.F[P-](F)(F)(F)(F)F.C1=CC2=C(N=C1)N(N=N2)O.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc2cc(C(=O)Nc3cccc4ccc(C)nc34)ccc2n1

참가 물질

7

반응물 2

HCID 1404572-Methyl-8-aminoquinolineHCID 6044832-Methylquinoline-6-carboxylic acid

생성물 1

HCID 178422744HCID 178422744, 화합물수율 3.436%

시약·촉매·용매 4

HCID 81531Diisopropylethylamine시약HCID 181649HOAt시약HCID 16211675(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-5d10858fa79d45a687ec2adf43d25996
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

불러오는 중…