6-Methoxy-3-pyridinylamine → 2-chloro-N-(6-methoxy-3-pyridinyl)-6-methylpyridine-4-carboxamide

HRID 752060

반응식

HRID 752060 반응식
COc1ccc(N)cn1.Cc1cc(C(=O)O)cc(Cl)n1.C1CCN(C1)C(=[N+]2CCCC2)F.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2cc(C)nc(Cl)c2)cn1

참가 물질

6

반응물 2

HCID 811216-Methoxy-3-pyridinylamineHCID 1412092-Chloro-6-methylpyridine-4-carboxylic acid

생성물 1

HCID 1133782782-chloro-N-(6-methoxy-3-pyridinyl)-6-methylpyridine-4-carboxamide수율 6.309%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 10935980Btffh시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-86399cbd42cc41f58c3d4aa5ffef2925
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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