Iodoethane → 3,5-Dichlorophenyl ethyl sulfide

HRID 75230

반응식

HRID 75230 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([SH:9])[CH:5]=[C:6]([Cl:8])[CH:7]=1.I[CH2:11][CH3:12].C(=O)([O-])[O-].[K+].[K+].C(Cl)Cl>O>[CH2:11]([S:9][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=1)[CH3:12]

참가 물질

6

반응물 4

HCID 6340IodoethaneHCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 27360963,5-Dichlorobenzenethiol

생성물 1

HCID 597520583,5-Dichlorophenyl ethyl sulfide수율 97.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3,5-dichlorobenzenethiol (1.50 g, 8.4 mmol), iodoethane (1.34 mL, 16.8 mmol), potassium carbonate (1.74 g, 12.6 mmol) and methylene chloride (10 mL) was stirred at 25° C. for 30 minutes. The reaction was diluted with water and extracted with ethyl acetate three times, dried over sodium sulfate, filtered and concentrated. The residue was purified by chromatography on silica gel to give the desired product (1.69 g, 97%). LC/MS: 207 (M+H)+.

후처리

  1. extractionextracted with ethyl acetate three times
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-9402da52b7b946efb3caf5900f1f5e5b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835423B2

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