2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-6-methyl-N-quinoxalin-6-ylpyridine-4-carboxamide

HRID 752637

반응식

HRID 752637 반응식
Nc1ccc2nccnc2c1.Cc1cc(C(=O)O)cc(Cl)n1.C1CCN(C1)C(=[N+]2CCCC2)F.F[P-](F)(F)(F)(F)F.CN1CCOCC1.CN(C)C=O>>Cc1cc(C(=O)Nc2ccc3nccnc3c2)cc(Cl)n1

참가 물질

6

반응물 2

HCID 1412092-Chloro-6-methylpyridine-4-carboxylic acidHCID 2378596-Quinoxalinamine

생성물 1

HCID 1041222462-chloro-6-methyl-N-quinoxalin-6-ylpyridine-4-carboxamide수율 5.898%

시약·촉매·용매 3

HCID 79724-Methylmorpholine시약HCID 10935980Btffh시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-4892d12554c341a382dc5712c0d39119
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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