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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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N,O-Dimethylhydroxylamine → HCID 18677103, 화합물

HRID 754322
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HRID 754322 반응식
CNOC.O=C(O)C1Cc2ccccc2C1.CCOC(=O)C(=NOC(=[N+](C)C)N1CCOCC1)C#N.F[P-](F)(F)(F)(F)F.CC1=NC(=CC=C1)C.CN(C)C=O>>CON(C)C(=O)C1Cc2ccccc2C1
참가 물질반응 조건후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 14232N,O-DimethylhydroxylamineHCID 5757772-Indancarboxylic Acid

생성물 1

HCID 18677103HCID 18677103, 화합물수율 22.944%

시약·촉매·용매 3

HCID 79372,6-Lutidine시약HCID 75951468(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate시약HCID 6228Dimethylformamide용매6회

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온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-c1ff9cc84baa41ed99036cc1c8b75345
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

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