Hydrazine hydrate (1:1) → HCID 178422720, 화합물

HRID 75511

반응식

HRID 75511 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=O)[CH2:8][C:9](=O)[CH3:10])[CH:2]=1.O.[NH2:14][NH2:15]>CO>[CH3:10][C:9]1[CH:8]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[NH:14][N:15]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 3001601-(Pyridin-3-yl)butane-1,3-dione

생성물 1

HCID 178422720HCID 178422720, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Pyridin-3-yl-butane-1,3-dione (step 1) (500 mg, 3.06 mmol) was dissolved in MeOH (20 ml). Hydrazine monohydrate (230 mg, 223 μl, 4.60 mmol) was added and the resulting mixture was stirred at RT for 1 hour. After cooling to RT, the solvent was removed in vacuo. The crude residue was dissolved in DCM, dried over (MgSO4) filtered and concentrated in vacuo to afford the title compound which was used without further purification.

후처리

  1. temperatureAfter cooling to RT
  2. customthe solvent was removed in vacuo
  3. dissolutionThe crude residue was dissolved in DCM
  4. dry with materialdried over (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8ec2aed3230440bc91c59ac10514a757
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835444B2

연결된 노트

불러오는 중…