Nitric Acid → 4-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde

HRID 75711

반응식

HRID 75711 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:19]([O-])([OH:21])=[O:20]>>[CH2:1]([O:8][C:9]1[C:10]([O:17][CH3:18])=[CH:11][C:12]([CH:13]=[O:14])=[C:15]([N+:19]([O-:21])=[O:20])[CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

생성물 1

HCID 5613634-(Benzyloxy)-5-methoxy-2-nitrobenzaldehyde수율 87%

실험 절차

Nitric acid (100 mL) was cooled to 0° C., 4-benzyloxy-3-methoxybenzaldehyde (20 g, 82.55 mmol) was added dropwise, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, distilled water was added thereto and the mixture was stirred for 30 min, followed by filtration of the solid to obtain the title compound (20.52 g, 87%).

후처리

  1. customAfter completion of the reaction
  2. distillationdistilled water
  3. additionwas added
  4. stirringthe mixture was stirred for 30 min
  5. filtrationfollowed by filtration of the solid

출처 및 근거

ORD 기록
ord-829124fe01be4f0d845d1c70aca583ab
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835458B2

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