Benzyl Chloride → Methyl 2,3-bis(benzyloxy)benzoate

HRID 76088

반응식

HRID 76088 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[O:11][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 7503Benzyl ChlorideHCID 75484Methyl 2,3-Dihydroxybenzoate

생성물 1

HCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

실험 절차

In one embodiment, the compounds can be prepared as shown in Scheme II. A dihydroxy benzoic acid methyl ester is reacted with benzyl chloride, to produce a Bis-benzyloxy benzoic acid methyl ester (1). The Bis-benzyloxy benzoic acid methyl ester can then be heated with LiOH to give a Bis-benzyloxy benzoic acid (2). The Bis-benzyloxy benzoic acid (2) is then reacted with an aminophenyl to produce a phenyl-benzamide (3). The phenyl-benzamide (3) is then reacted with hydrazine to give a triazol (4). The hydroxy groups can then be unprotected in the presence of palladium on charcoal to give the final product.

후처리

  1. customIn one embodiment, the compounds can be prepared

출처 및 근거

ORD 기록
ord-ebfc6169a3ab4ce89cf4bf4ea3f92fa0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835464B2

연결된 노트

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