2-(4-Bromophenyl)propanenitrile → 2-(4-Bromophenyl)propan-1-amine

HRID 76145노트

반응식

HRID 76145 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:11])[C:9]#[N:10])=[CH:4][CH:3]=1>[Ni].N>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:11])[CH2:9][NH2:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 107509272-(4-Bromophenyl)propanenitrile

생성물 1

HCID 107986602-(4-Bromophenyl)propan-1-amine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

A mixture of 3.00 g (14.3 mmol) 2-(4-bromo-phenyl)-propionitrile and 40 mL ammonia solution (7N in methanol) is charged with 0.30 g Raney nickel. The mixture is stirred under an atmosphere of hydrogen (50 psi) at r.t. for 34 h. The mixture is filtered and the solvent is removed in vacuo. The crude product is used without further purification.

후처리

  1. filtrationThe mixture is filtered
  2. customthe solvent is removed in vacuo
  3. customThe crude product is used without further purification

출처 및 근거

ORD 기록
ord-5ebc63f5e247468e89ccb9bbfd6ddfc8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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