N-(1-(4-Iodophenyl)propan-2-YL)acetamide → 4-Iodo-alpha-methylbenzeneethanamine

HRID 76163노트

반응식

HRID 76163 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:11]C(=O)C)[CH3:10])=[CH:4][CH:3]=1>Cl>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([NH2:11])[CH3:10])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 66611344N-(1-(4-Iodophenyl)propan-2-YL)acetamide

생성물 1

HCID 1238704-Iodo-alpha-methylbenzeneethanamine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9.00 g (29.69 mmol) N-[2-(4-iodo-phenyl)-1-methyl-ethyl]-acetamide (I52.1) are added to 150 mL HCl (4N) and the reaction mixture is stirred at reflux over night. Then the mixture is diluted with soda lye and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

후처리

  1. temperatureat reflux over night
  2. additionThen the mixture is diluted with soda lye
  3. extractionextracted with EtOAc
  4. dry with materialThe organic layer is dried with Na2SO4
  5. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-6972a19953ff4a0ca677f361275db46a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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