3-Pentanol → N-(1-(4-((4-(pentan-3yloxy)phenyl)ethynyl)phenyl)propan-2-yl)acetamide

HRID 76188노트

반응식

HRID 76188 반응식
[CH3:1][CH2:2][CH:3]([OH:6])[CH2:4][CH3:5].O[C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH:23]([NH:25][C:26](=[O:28])[CH3:27])[CH3:24])=[CH:18][CH:17]=2)=[CH:10][CH:9]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1C=CC(COC(/N=N/C(OCC2C=CC=CC=2)=O)=O)=CC=1>C1COCC1>[CH3:1][CH2:2][CH:3]([O:6][C:8]1[CH:9]=[CH:10][C:11]([C:14]#[C:15][C:16]2[CH:17]=[CH:18][C:19]([CH2:22][CH:23]([NH:25][C:26](=[O:28])[CH3:27])[CH3:24])=[CH:20][CH:21]=2)=[CH:12][CH:13]=1)[CH2:4][CH3:5]

참가 물질

6

반응물 4

HCID 114283-Pentanol2회HCID 11776TriphenylphosphineHCID 5387121Dibenzyl azodicarboxylate2회HCID 66610715N-(1-(4-((4-hydroxyphenyl)ethynyl)phenyl)propan-2-yl)acetamide

생성물 1

HCID 66635135N-(1-(4-((4-(pentan-3yloxy)phenyl)ethynyl)phenyl)propan-2-yl)acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

14.7 μl (0.14 mmol) 3-pentanol, 40 mg (0.14 mmol) N-(1-(4-((4-hydroxyphenyl)-ethynyl)phenyl)propan-2-yl)acetamide (I74.1) and 69.8 mg (0.21 mmol) polymer bound triphenylphosphine (˜3 mmol/g) are added to 1 mL THF followed by 31.4 mg (0.14 mmol) DBAD. After stirring the mixture for 2 h at r.t. further 7.5 μl (0.07 mmol) 3-pentanol and 16 mg (0.07 mmol) DBAD are added and stirring is continued for 72 h. The reaction mixture is filtered and the filtrate is purified by HPLC (MeOH/H2O/TFA).

후처리

  1. additionare added
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is purified by HPLC (MeOH/H2O/TFA)

출처 및 근거

ORD 기록
ord-86e3c76596964071acb15c0d3b034fdc
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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