Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethoxy-4-ethynylbenzene → N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethoxy-4-ethynylbenzene | HCID 2775124 | — |
| 반응물 | N-(4-iodophen-ethyl)propionamide | HCID 66611251 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sec-Butylamine | HCID 24874 | — |
| 생성물 | N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide | HCID 66611159 | — |
반응 단계
150 mg (1.03 mmol) 1-ethoxy-4-ethynylbenzene, 327 mg (1.08 mmol) N-(4-iodophen-ethyl)propionamide (I47.2) and 36 mg (0.05 mmol) bis(triphenylphosphine)dichloro-palladium in 2.0 mL water and 1.5 mL sec-butylamine are stirred at r.t. over night and for additional 4 h at 30° C. The reaction mixture is partitioned between DCM and water. The solvent of the organic layer is evaporated in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835472B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-02e93700f2474a85ae967845e3e81f03 |
| 출처 메모 | uspto-grants-2014_09 |