Triethylamine → HCID 178418938, 화합물

HRID 7623

반응식

HRID 7623 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][C:11]1[CH:15]=[C:14]([CH:16]2[CH2:18][CH2:17]2)[NH:13][N:12]=1.C(N(CC)CC)C>CCO>[CH:16]1([C:14]2[CH:15]=[C:11]([NH:10][C:6]3[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([Cl:1])[N:7]=3)[NH:12][N:13]=2)[CH2:18][CH2:17]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 773782,4,6-TrichloropyrimidineHCID 27580143-cyclopropyl-1H-pyrazol-5-amine

생성물 1

HCID 178418938HCID 178418938, 화합물수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of-2,4,6-trichloropyrimidine (600 mg, 3.27 mmol) and 3-amino-5-cyclopropylpyrazole (403 mg, 3.27 mmol) in EtOH (10 mL) was added triethylamine (456 μL, 3.27 mmol) and the reaction mixture was stirred for 15 hours at room temperature. The solvent was evaporated and the residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient) to afford (5-cyclopropyl-2H-pyrazol-3-yl-)-(2,6-dichloropyrimidin-4-yl)-amine (705 mg, 80%).

후처리

  1. customThe solvent was evaporated
  2. customthe residue was purified by flash chromatography (SiO2, Hexane/AcOEt gradient)

출처 및 근거

ORD 기록
ord-35c861d6b82946f599930c0c25b7c1b1
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087603B2

연결된 노트

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