1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester → Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]-methylamino}ethyl ester

HRID 76242노트

반응식

HRID 76242 반응식
C(CNCC(O[C:15]([C:17]1([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=3)=[C:22]([F:34])[CH:21]=2)[CH2:19][CH2:18]1)=[O:16])CNCC(=O)C)(=O)C.C([CH2:38][NH:39][CH2:40][CH:41]([O:65][C:66](=[O:68])[CH3:67])[CH2:42][NH:43][CH2:44][C:45]([C:47]1(C2C=CC(C3C=CC(Cl)=C(Cl)C=3)=C(F)C=2)CC1)=[O:46])(=O)C>CN(C1C=CN=CC=1)C>[C:45]([CH2:44][NH:43][CH2:42][CH:41]([O:65][C:66](=[O:68])[CH3:67])[CH2:40][N:39]([C:15]([C:17]1([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=3)=[C:22]([F:34])[CH:21]=2)[CH2:19][CH2:18]1)=[O:16])[CH3:38])(=[O:46])[CH3:47]

참가 물질

4

반응물 2

HCID 866988931-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester2회HCID 86698894Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]methylamino}ethyl ester

생성물 1

HCID 86698892Acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]-methylamino}ethyl ester

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

Note that although the procedure is similar to that utilized to synthesize C4 (second method, see Example 5), with the exception that also DMAP was added in the coupling step of Example 5 but not of Example 6, the isolated product is different, being acetic acid 1-[(acetylmethylamino)methyl]-2-{[1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarbonyl]methylamino}ethyl ester in Example 6 and 1-(3′,4′-dichloro-2-fluorobiphenyl-4-yl)cyclopropane carboxylic acid 2-acetylmethylamino-1-(acetylmethylaminomethyl)ethyl ester in Example 5.

출처 및 근거

ORD 기록
ord-2ade16eee5484b7081ed8e646a8ab0a8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835494B2

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