Iodine → ethyl (NZ)-N-[4-butyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-thiazol-5-ylidene]carbamate

반응식

[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[F:8][C:9]([F:15])([F:14])[C:10]([CH3:13])([NH2:12])[CH3:11].[C:16]([N:21]=[C:22]=[S:23])(=[O:20])[O:17][CH2:18][CH3:19].II>>[CH2:3]([C:2]1=[CH:1][N:12]([C:10]([CH3:13])([CH3:11])[C:9]([F:15])([F:14])[F:8])[S:23]/[C:22]/1=[N:21]\[C:16](=[O:20])[O:17][CH2:18][CH3:19])[CH2:4][CH2:5][CH3:6]

참가 물질

반응물 4

HCID 807Iodine

HCID 6184Hexanal

HCID 85320Ethyl isothiocyanatoformate

HCID 112751881,1,1-Trifluoro-2-methylpropan-2-amine

생성물 1

HCID 87184182ethyl (NZ)-N-[4-butyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-thiazol-5-ylidene]carbamate

실험 절차

Commercially available hexanal (Aldrich), 1,1,1-trifluoro-2-methylpropan-2-amine (Chemcollect), O-ethyl carbonisothiocyanatidate (Aldrich) and iodine were processed using the method described in Example 110A to afford the title compound. MS (ESI+) m/z 339 (M+H)+.

출처 및 근거

ORD 기록: ord-2cd5d913d41e441eb5cc445ddd0aa78f
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08835475B2

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