Tetrahydrofuran → 2-ethyl-4-(perfluorophenylcarbonyl)-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

HRID 76343

반응식

HRID 76343 반응식
[F:1][C:2]1[C:7]([C:8](Cl)=[O:9])=[C:6]([F:11])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[F:14].[H-].[Na+].O1[CH:22]=[CH:21][CH2:20][C:19](=[O:23])[NH:18]1.[CH2:24]1[CH2:28][O:27][CH2:26][CH2:25]1>>[CH2:21]([CH:20]1[O:27][C:26]2[C:2]([CH:3]=[CH:4][CH3:5])=[CH:7][CH:28]=[CH:24][C:25]=2[N:18]([C:8]([C:7]2[C:2]([F:1])=[C:3]([F:14])[C:4]([F:13])=[C:5]([F:12])[C:6]=2[F:11])=[O:9])[C:19]1=[O:23])[CH3:22]

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 75256Pentafluorobenzoyl chlorideHCID 21873527Oxazinone

생성물 1

HCID 1317318752-ethyl-4-(perfluorophenylcarbonyl)-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one수율 63%

실험 절차

Procedure & NMR Data: 265 μL of pentafluorobenzoyl chloride (2 eq, 1.84 mmol) was added to a mixture of 148 mg of NaH (4 eq, 3.68 mmol) and 200 mg (0.92 mmol) of oxazinone P2 in THF (22 ml). 240 mg of P5 were obtained, yield 63%.

후처리

  1. custom240 mg of P5 were obtained

출처 및 근거

ORD 기록
ord-0753b1db55304e0794165cca15c7aa25
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835628B2

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