Hydrochloric Acid → 2-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride
반응식
C(OC([N:8]1[CH2:13][CH:12]([CH3:14])[N:11]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(O)C>[ClH:22].[CH3:21][CH:10]1[CH2:9][NH:8][CH2:13][CH:12]([CH3:14])[N:11]1[C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1참가 물질
4
실험 절차
3,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester (294 mg) was dissolved in ethanol (2 ml), 4N hydrochloric acid (ethyl acetate solution, 2 ml) was added and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated, and ethyl acetate (3 ml) was added to the obtained residue. The solid insoluble in ethyl acetate was collected by filtration and dried to give the title compound (281 mg).
후처리
- customThe solvent was evaporated
- additionethyl acetate (3 ml) was added to the obtained residue
- filtrationThe solid insoluble in ethyl acetate was collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-0f6935ec524f430c8a1dde00e0ae3fff
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08835631B2
반응 노트
불러오는 중…