Hydrochloric Acid → Benzyl 4-methylidenepyrazolidine-1-carboxylate
반응식
C(OC([N:8]1[CH2:12][C:11](=[CH2:13])[CH2:10][N:9]1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=O)(C)(C)C.S(Cl)(Cl)=O.Cl>CO>[CH2:17]([O:16][C:14]([N:9]1[CH2:10][C:11](=[CH2:13])[CH2:12][NH:8]1)=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1참가 물질
5
실험 절차
To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 8, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.
후처리
- customConcentration of the reaction in vacuo
- customaffords a yellow oil which
- customcrystallizes
출처 및 근거
- ORD 기록
- ord-9f5a1084af704e6c96cab63ed63b299d
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087615B2
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