2-Aminophenol → 3-bromo-N-(2-hydroxyphenyl)4-methylbenzamide

HRID 7681

반응식

HRID 7681 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=O.S(Cl)(Cl)=O.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23].C(N(C(C)C)CC)(C)C>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23])=[O:7]

참가 물질

6

반응물 4

HCID 58012-AminophenolHCID 24386Thionyl ChlorideHCID 81531DiisopropylethylamineHCID 821303-Bromo-4-methylbenzoic acid

생성물 1

HCID 219909653-bromo-N-(2-hydroxyphenyl)4-methylbenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3-bromo-4-methylbenzoic acid (1.0 g, 4.7 mmol) and thionyl chloride (18 mL) was refluxed for 1 h and then cooled to rt. The excess thionyl chloride was removed in vacuo, the residue was dissolved in THF (10 mL), and was added to a cooled (0° C.) mixture of 2-aminophenol (510 mg, 4.7 mmol) and diisopropylethylamine (0.90 mL, 5.1 mmol) in THF (18 mL). The resulting mixture was stirred at rt for 4 h. The solvent was then removed and the residue was purified by flash chromatography on silica gel eluting with EtOAc:hexane (1:5 to 1:4) to afford 3-bromo-N-(2-hydroxyphenyl)-4-methylbenzamide.

후처리

  1. temperaturewas refluxed for 1 h
  2. customThe excess thionyl chloride was removed in vacuo
  3. dissolutionthe residue was dissolved in THF (10 mL)
  4. additionwas added to
  5. temperaturea cooled
  6. customThe solvent was then removed
  7. customthe residue was purified by flash chromatography on silica gel eluting with EtOAc:hexane (1:5 to 1:4)

출처 및 근거

ORD 기록
ord-e4a2a72cc2724411b370e0075895332a
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087601B2

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