Hydrochloric Acid → (R)-(4-fluoro-phenylamino)-phenyl-acetic acid

HRID 77052노트

반응식

HRID 77052 반응식
C[O:2][C:3](=[O:19])[C@H:4]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl>O1CCOCC1>[F:18][C:15]1[CH:16]=[CH:17][C:12]([NH:11][C@H:4]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:3]([OH:19])=[O:2])=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59401123(R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

생성물 1

HCID 7006576(R)-(4-fluoro-phenylamino)-phenyl-acetic acid수율 87%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
70 °C

실험 절차

To a solution of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (I252) (510 mg, 1.97 mmol) in dioxane (10 mL), is added 12N HCl (10 mL) and the mixture is heated at 70° C. for 12 hours. The organic solvent is evaporated, the mixture is cooled to 0° C. and the resulting solid is collected by filtration to obtain intermediate I255 as a brownish solid (420 mg, 87% yield).

후처리

  1. customThe organic solvent is evaporated
  2. temperaturethe mixture is cooled to 0° C.
  3. filtrationthe resulting solid is collected by filtration
  4. customto obtain intermediate

출처 및 근거

ORD 기록
ord-ca0cfb9e27b8439b9066a740e8f09515
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835682B2

반응 노트

불러오는 중…