Dichloromethane → {(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidin-3-yl}-piperazin-1-yl-methanone hydrochloride

HRID 77088노트

반응식

HRID 77088 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C@H:16]2[CH2:21][CH2:20][CH2:19][N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]4[N:32]([CH3:33])[C:31]5[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=5[N:29]=4)[CH:23]=3)[CH2:17]2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:38]CCl>Cl.CCOCC>[ClH:38].[CH3:33][N:32]1[C:31]2[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=2[N:29]=[C:28]1[C:24]1[CH:23]=[C:22]([N:18]2[CH2:19][CH2:20][CH2:21][C@H:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:15])[CH2:17]2)[CH:27]=[CH:26][CH:25]=1

참가 물질

5

반응물 2

HCID 6344DichloromethaneHCID 669774704-{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-3-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 66977509{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidin-3-yl}-piperazin-1-yl-methanone hydrochloride

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3283Diethyl Ether용매

실험 절차

Method A—Step b To a mixture of 4-{(S)-1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-3-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester (0.04 g, 0.08 mmol) in dichloromethane (0.5 mL), 2M HCl in Et2O (2 mL) was added and the resulting mixture was stirred overnight at room temperature. Solvent was removed to get 0.04 g of the title compound as hydrochloride salt with quantitative yield.

후처리

  1. additionwas added
  2. customSolvent was removed

출처 및 근거

ORD 기록
ord-7e87aa508d2c49488bc7b41343fadb2a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835648B2

반응 노트

불러오는 중…